Somatic mutations in chromatin remodeler genes could modify the epigenomic landscape of CLL, but These are uncommon With this malignancy as compared to other lymphoid neoplasms. CHD2 is mutated in five% of CLL and 7% of MBL.seventy five The histone methyltransferase SETD2 and ARID1A may also be mutated in a small proportion of clients. Of Take note